abstract：OBJECTIVE:To characterize physiologic subtypes of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity and secretion were estimated in 809 women at 24-30 weeks' gestation, using oral glucose tolerance test-based indices. In women with GDM (8.3%), defects in insulin sensitivity or secret...

journal_title：Diabetes care

authors： Powe CE,Allard C,Battista MC,Doyon M,Bouchard L,Ecker JL,Perron P,Florez JC,Thadhani R,Hivert MF

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes. RESEARCH DESIGN AND METHODS:We searched MEDLINE and EMBASE databases through August 2015. We conducted a q...

journal_title：Diabetes care

authors： Guasch-Ferré M,Hruby A,Toledo E,Clish CB,Martínez-González MA,Salas-Salvadó J,Hu FB

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Previous studies demonstrate that the metabolic syndrome is associated with distal symmetric polyneuropathy (DSP). We aimed to determine the magnitude of this effect and the precise components involved. RESEARCH DESIGN AND METHODS:We determined the symptomatic DSP prevalence in the Health, Aging, and Body Co...

journal_title：Diabetes care

authors： Callaghan BC,Xia R,Banerjee M,de Rekeneire N,Harris TB,Newman AB,Satterfield S,Schwartz AV,Vinik AI,Feldman EL,Strotmeyer ES,Health ABC Study.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To examine the magnitude and types of hospitalizations among persons with prediabetes, undiagnosed diabetes, and diagnosed diabetes. RESEARCH DESIGN AND METHODS:This study included 13,522 participants in the Atherosclerosis Risk in Communities (ARIC) study (mean age 57 years, 56% female, 24% black, 18% with ...

journal_title：Diabetes care

authors： Schneider AL,Kalyani RR,Golden S,Stearns SC,Wruck L,Yeh HC,Coresh J,Selvin E

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:The Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial reported neutral effects of insulin glargine on cardiovascular outcomes and cancers and reduced incident diabetes in high-cardiovascular risk adults with dysglycemia after 6.2 years of active treatment. Omega-3 fatty acids had neutral eff...

journal_title：Diabetes care

authors： ORIGIN Trial Investigators.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:This study examined whether lipids modify the relationship between intensive glucose control (INT) and diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS:The incidence and progression of DR were assessed in 858 of 1,791 participants with 7-field stereoscopic fundus photographs at baseline and 5 years lat...

journal_title：Diabetes care

authors： Azad N,Bahn GD,Emanuele NV,Agrawal L,Ge L,Reda D,Klein R,Reaven PD,Hayward R,VADT Study Group.

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized that air pollution adversely affects insulin sensitivity and secretion and serum lipid levels. RESEARCH DESIGN AND METHO...

journal_title：Diabetes care

authors： Chen Z,Salam MT,Toledo-Corral C,Watanabe RM,Xiang AH,Buchanan TA,Habre R,Bastain TM,Lurmann F,Wilson JP,Trigo E,Gilliland FD

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:In 2010, the American Diabetes Association (ADA) added hemoglobin A1c (A1C) to the guidelines for diagnosing type 2 diabetes. However, existing models for predicting diabetes risk were developed prior to the widespread adoption of A1C. Thus, it remains unknown how well existing diabetes risk prediction models...

journal_title：Diabetes care

authors： Lacy ME,Wellenius GA,Carnethon MR,Loucks EB,Carson AP,Luo X,Kiefe CI,Gjelsvik A,Gunderson EP,Eaton CB,Wu WC

更新日期：2016-02-01 00:00:00

abstract：:Diabetes is more common in older adults, has a high prevalence in long-term care (LTC) facilities, and is associated with significant disease burden and higher cost. The heterogeneity of this population with regard to comorbidities and overall health status is critical to establishing personalized goals and treatments...

journal_title：Diabetes care

authors： Munshi MN,Florez H,Huang ES,Kalyani RR,Mupanomunda M,Pandya N,Swift CS,Taveira TH,Haas LB

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:Diet therapy in gestational diabetes mellitus (GDM) has focused on carbohydrate restriction but is poorly substantiated. In this pilot randomized clinical trial, we challenged the conventional low-carbohydrate/higher-fat (LC/CONV) diet, hypothesizing that a higher-complex carbohydrate/lower-fat (CHOICE) diet ...

journal_title：Diabetes care

authors： Hernandez TL,Van Pelt RE,Anderson MA,Reece MS,Reynolds RM,de la Houssaye BA,Heerwagen M,Donahoo WT,Daniels LJ,Chartier-Logan C,Janssen RC,Friedman JE,Barbour LA

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and safety of prandial Technosphere inhaled insulin (TI), an inhaled insulin with a distinct time action profile, in insulin-naïve type 2 diabetes (T2D) inadequately controlled on oral antidiabetes agents (OADs). RESEARCH DESIGN AND METHODS:Subjects with T2D with HbA1c levels ≥7.5...

journal_title：Diabetes care

authors： Rosenstock J,Franco D,Korpachev V,Shumel B,Ma Y,Baughman R,Amin N,McGill JB,Affinity 2 Study Group.

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes. RESEARCH DESIGN AND METHODS:The Women's Heal...

journal_title：Diabetes care

authors： Espeland MA,Brinton RD,Hugenschmidt C,Manson JE,Craft S,Yaffe K,Weitlauf J,Vaughan L,Johnson KC,Padula CB,Jackson RD,Resnick SM,WHIMS Study Group.

更新日期：2015-12-01 00:00:00

abstract：:Type 2 diabetes is a chronic disease with disabling micro- and macrovascular complications that lead to excessive morbidity and premature mortality. It affects hundreds of millions of people and imposes an undue economic burden on populations across the world. Although insulin resistance and insulin secretory defects ...

journal_title：Diabetes care

authors： Mudaliar S,Polidori D,Zambrowicz B,Henry RR

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat...

journal_title：Diabetes care

authors： Díaz-López A,Babio N,Martínez-González MA,Corella D,Amor AJ,Fitó M,Estruch R,Arós F,Gómez-Gracia E,Fiol M,Lapetra J,Serra-Majem L,Basora J,Basterra-Gortari FJ,Zanon-Moreno V,Muñoz MÁ,Salas-Salvadó J,PREDIMED Study Inves

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:We examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS:Between 1989 and...

journal_title：Diabetes care

authors： Strand LB,Carnethon M,Biggs ML,Djoussé L,Kaplan RC,Siscovick DS,Robbins JA,Redline S,Patel SR,Janszky I,Mukamal KJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:This study estimated the screening prevalence of prediabetes and diabetes using a lower BMI cutoff of 23 kg/m(2) in Asians in the U.S. using the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2012. RESEARCH DESIGN AND METHODS:A cross-sectional analysis was conducted of non-Hispanic As...

journal_title：Diabetes care

authors： Hsia DS,Larrivee S,Cefalu WT,Johnson WD

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To determine whether the use of glyburide is associated with an increased risk of cancer compared with the use of other second-generation sulfonylureas among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS:The U.K. Clinical Practice Research Datalink was used to conduct a cohort study among 52,600...

journal_title：Diabetes care

authors： Tuccori M,Wu JW,Yin H,Majdan A,Azoulay L

更新日期：2015-11-01 00:00:00

abstract：:Type 1 diabetes (T1D) and celiac disease (CeD) cluster in families and can occur in the same individual. Genetic loci have been associated with susceptibility to both diseases. Our aim was to explore the genetic differences between individuals developing both these diseases (double autoimmunity) versus those with only...

journal_title：Diabetes care

authors： Gutierrez-Achury J,Romanos J,Bakker SF,Kumar V,de Haas EC,Trynka G,Ricaño-Ponce I,Steck A,Type 1 Diabetes Genetics Consortium.,Chen WM,Onengut-Gumuscu S,Simsek S,Diabeter.,Rewers M,Mulder CJ,Liu E,Rich SS,Wijmenga C

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

journal_title：Diabetes care

authors： Ozieh MN,Bishu KG,Dismuke CE,Egede LE

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the presence and correlates of clinically relevant cognitive impairment in middle-aged adults with childhood-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:During 2010-2013, 97 adults diagnosed with T1D and aged <18 years (age and duration 49 ± 7 and 41 ± 6 ...

journal_title：Diabetes care

authors： Nunley KA,Rosano C,Ryan CM,Jennings JR,Aizenstein HJ,Zgibor JC,Costacou T,Boudreau RM,Miller R,Orchard TJ,Saxton JA

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility and efficacy of a fully integrated hybrid closed-loop (HCL) system (Medtronic MiniMed Inc., Northridge, CA), in day and night closed-loop control in subjects with type 1 diabetes, both in an inpatient setting and during 6 days at diabetes camp. RESEARCH DESIGN AND METHODS:The Medt...

journal_title：Diabetes care

authors： Ly TT,Roy A,Grosman B,Shin J,Campbell A,Monirabbasi S,Liang B,von Eyben R,Shanmugham S,Clinton P,Buckingham BA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:No prospective, community-based cohort studies have investigated the association between blood pressure and diabetes in Asian ethnicity. We investigated this issue in a 10-year prospective, community-based study of Koreans. RESEARCH DESIGN AND METHODS:We studied whether high blood pressure was associated wit...

journal_title：Diabetes care

authors： Cho NH,Kim KM,Choi SH,Park KS,Jang HC,Kim SS,Sattar N,Lim S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:There is considerable interest in identifying biomarkers that predict high risk for the development of macrovascular complications in patients with diabetes. Therefore, the longitudinal association between subclinical atherosclerosis as measured by internal carotid artery intima-media thickness (IMT) and acut...

journal_title：Diabetes care

authors： Hunt KJ,Baker NL,Cleary PA,Klein R,Virella G,Lopes-Virella MF,DCCT\/EDIC Group of Investigators.

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence of diabetes and prediabetes and the associated risk factors in two Asian Indian populations living in different environments. RESEARCH DESIGN AND METHODS:We performed cross-sectional analyses, using representative samples of 2,305 Asian Indians aged 40-84 years living in Chennai, Ind...

journal_title：Diabetes care

authors： Gujral UP,Narayan KM,Pradeepa RG,Deepa M,Ali MK,Anjana RM,Kandula NR,Mohan V,Kanaya AM

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To establish quantitative characteristics of lifestyle counseling documentation associated with improved glycemic control in patients with diabetes. RESEARCH DESIGN AND METHODS:We retrospectively studied 10,870 hyperglycemic (HbA1c ≥7.0% [53 mmol/mol]) adults with diabetes followed at primary care practices ...

journal_title：Diabetes care

authors： Hosomura N,Goldberg SI,Shubina M,Zhang M,Turchin A

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS:In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood draw...

journal_title：Diabetes care

authors： Wang Q,Imamura F,Ma W,Wang M,Lemaitre RN,King IB,Song X,Biggs ML,Delaney JA,Mukamal KJ,Djousse L,Siscovick DS,Mozaffarian D

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. RESEARCH DESIGN AND METHODS:The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the Trial...

journal_title：Diabetes care

authors： Sosenko JM,Skyler JS,Beam CA,Boulware D,Mahon JL,Krischer JP,Greenbaum CJ,Rafkin LE,Matheson D,Herold KC,Palmer JP,Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Emerging evidence suggests that peripheral neuropathy begins in the early stages of diabetes pathogenesis. Our objective was to describe the prevalence of peripheral neuropathy and nerve dysfunction according to glucose tolerance and metabolic syndrome status and examine how these conditions are associated wi...

journal_title：Diabetes care

authors： Lee CC,Perkins BA,Kayaniyil S,Harris SB,Retnakaran R,Gerstein HC,Zinman B,Hanley AJ

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of parenteral insulin therapy on endogenous insulin secretion in the Diabetes Prevention Trial-Type 1 (DPT-1). RESEARCH DESIGN AND METHODS:In the parenteral insulin arm of DPT-1, subjects without diabetes at high risk of future type 1 diabetes randomized to active treatment received...

journal_title：Diabetes care

authors： Hao W,Greenbaum CJ,Krischer JP,Cuthbertson D,Marks JB,Palmer JP

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:This study examined the long-term consequences for offspring born to mothers with pregestational type 1 diabetes regarding mortality, hospital admissions, and medication. We also examined the association between HbA1c levels during pregnancy and mortality and incidence of hospital admissions. RESEARCH DESIGN...

journal_title：Diabetes care

authors： Knorr S,Stochholm K,Vlachová Z,Bytoft B,Clausen TD,Jensen RB,Juul S,Ovesen P,Damm P,Beck-Nielsen H,Jensen DM,Gravholt CH

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Women with preexisting (type 1 or type 2) diabetes experience an increased risk of serious adverse pregnancy outcomes. It is not known, however, how these risks change between the first and second pregnancy and whether there is an increased risk of recurrence. This study describes the absolute risks and recur...

journal_title：Diabetes care

authors： Tennant PW,Bilous RW,Prathapan S,Bell R

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:This study analyzed the lifetime health care expenditures and life years lost associated with diabetes in the U.S. RESEARCH DESIGN AND METHODS:Data from the National Health Interview Survey (NHIS), the Medical Expenditure Panel Survey from 1997 to 2000, and the NHIS Linked Mortality Public-use Files with a m...

journal_title：Diabetes care

authors： Leung MY,Pollack LM,Colditz GA,Chang SH

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To compare pharmacokinetics (PK) and pharmacodynamics (PD) of insulin glargine in type 2 diabetes mellitus (T2DM) after evening versus morning administration. RESEARCH DESIGN AND METHODS:Ten T2DM insulin-treated persons were studied during 24-h euglycemic glucose clamp, after glargine injection (0.4 units/kg...

journal_title：Diabetes care

authors： Porcellati F,Lucidi P,Cioli P,Candeloro P,Marinelli Andreoli A,Marzotti S,Ambrogi M,Bolli GB,Fanelli CG

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To assess the dose-ranging efficacy and safety of LX4211, a dual inhibitor of sodium-glucose cotransporter (SGLT) 1 and SGLT2, in type 2 diabetes. RESEARCH DESIGN AND METHODS:Type 2 diabetic patients inadequately controlled on metformin were randomly assigned to 75 mg once daily, 200 mg once daily, 200 mg tw...

journal_title：Diabetes care

authors： Rosenstock J,Cefalu WT,Lapuerta P,Zambrowicz B,Ogbaa I,Banks P,Sands A

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:A common variant rs236918 in the PCSK7 gene has the strongest association with iron homeostasis and is related to insulin resistance. Dietary carbohydrate (CHO) modulates the genetic effect on insulin resistance. We examined whether 2-year weight-loss diets modify the effect of PCSK7 genetic variants on chang...

journal_title：Diabetes care

authors： Huang T,Huang J,Qi Q,Li Y,Bray GA,Rood J,Sacks FM,Qi L

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS:High-throughput ...

journal_title：Diabetes care

authors： Kemppainen KM,Ardissone AN,Davis-Richardson AG,Fagen JR,Gano KA,León-Novelo LG,Vehik K,Casella G,Simell O,Ziegler AG,Rewers MJ,Lernmark Å,Hagopian W,She JX,Krischer JP,Akolkar B,Schatz DA,Atkinson MA,Triplett EW,TED

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:HbA1c is strongly related to the development of diabetes complications, but it is still controversial which HbA1c level to strive for in the treatment of type 1 diabetes. The aim of the current study was to evaluate HbA1c, followed from diagnosis, as a predictor of severe microvascular complications and to fo...

journal_title：Diabetes care

authors： Nordwall M,Abrahamsson M,Dhir M,Fredrikson M,Ludvigsson J,Arnqvist HJ

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:We aimed to study the association of breast-feeding duration and age at the introduction of solid foods with the risk of islet autoimmunity and type 1 diabetes in genetically susceptible children. RESEARCH DESIGN AND METHODS:Newborns were recruited from the Norwegian general population during 2001-2007. Afte...

journal_title：Diabetes care

authors： Lund-Blix NA,Stene LC,Rasmussen T,Torjesen PA,Andersen LF,Rønningen KS

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Several meta-analyses of observational studies suggested that metformin use reduces cancer risk in type 2 diabetes. However, this result was not confirmed by the few available randomized controlled trials (RCTs), and many observational studies on metformin and cancer were potentially afflicted with time-relat...

journal_title：Diabetes care

authors： Kowall B,Rathmann W,Kostev K

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Inflammatory processes have been implicated in the pathogenesis of painful neuropathy in rodents, but the relationship between inflammatory biomarkers and painful distal sensorimotor polyneuropathy (DSPN) has not been assessed in population-based studies. Therefore, we investigated whether circulating levels ...

journal_title：Diabetes care

authors： Herder C,Bongaerts BW,Rathmann W,Heier M,Kowall B,Koenig W,Thorand B,Roden M,Meisinger C,Ziegler D

更新日期：2015-01-01 00:00:00